Fish and marine fatty acids intakes, the genotypes and long-term weight gain: a prospective cohort study.

Objective: We tested whether genetic variants near fatty acid desaturases gene () cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).

Design: Three variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.

Setting: Population based study.