Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditions.

Introduction: Buspirone (CAS 33386-08-2) is reported to have anxiolytic effects in humans and is mostly described for mild anxiety. To further explore the effects of buspirone on different levels of anxiety, the effect of buspirone was evaluated in two different conditions of the open field which were distinguished as low and high anxiety (enclosed and exposed open field, respectively).

Materials And Methods: Twenty-eight albino Wistar rats (350-400 g) were tested in two different arena settings, an enclosed and an exposed open field.

Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation.

Intervening with serotonergic neurotransmission can have profound effects on mobility. For instance, the peripheral administration of the 5-HT(2A/C) agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), changes the locomotor activity substantially. Locomotor activity is classically linked to the basal ganglia, in which the subthalamic nucleus (STN) plays a pivotal role.