Publications by authors named "Rob Goble"

In 2019, the World Health Organization (WHO) named "Vaccine Hesitancy" one of the top 10 threats to global health. Shortly afterward, the COVID-19 pandemic emerged as the world's predominant health concern. COVID-19 vaccines of several types have been developed, tested, and partially deployed with remarkable speed; vaccines are now the primary control measure and hope for a return to normalcy.

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This article is one piece in a series of articles that reflect on advances in ideas about risk made by social science over the past 40 years and more. It differs from the other articles: its focus is not on specific advances themselves, but rather on how those advances were received and were encouraged or discouraged by the natural science and technical members of the risk community. Thus, the principal goal of this article is to provide some context for the other articlers in this series.

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In 1990 the U.S. Congress passed a law providing compensation to former uranium miners who became ill while the U.

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From World War II until 1971, the government was the sole purchaser of uranium ore in the United States. Uranium mining occurred mostly in the southwestern United States and drew many Native Americans and others into work in the mines and mills. Despite a long and well-developed understanding, based on the European experience earlier in the century, that uranium mining led to high rates of lung cancer, few protections were provided for US miners before 1962 and their adoption after that time was slow and incomplete.

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Article Synopsis
  • Pharmacokinetics of xenobiotics vary significantly between children and adults due to differences in physiology and immature enzyme systems, making adult dosage estimates for children uncertain.
  • A Children's PK Database was created, comparing pharmacokinetic parameters for 45 drugs between children and adults, showing that neonates generally have a longer half-life for these drugs, which normalizes by 2-6 months of age.
  • The findings indicate that the typical uncertainty factor used for interindividual variability may be insufficient for certain drugs during early infancy, suggesting the need for tailored risk assessment approaches for children regarding environmental toxicants.
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