Ten years of online incident reporting and learning using CPiRLS: implications for improved patient safety.

Background: Safety incident (SI) reporting and learning via incident reporting systems (IRSs) is used to identify areas for patient safety improvement. The chiropractic patient incident reporting and learning system (CPiRLS) is an online IRS that was launched in the UK in 2009 and, from time to time, has been licensed for use by the national members of the European Chiropractors' Union (ECU), members of Chiropractic Australia and a Canada-based research group. The primary aim of this project was to analyse the SIs submitted to CPiRLS over a 10-year period to identify key areas for patient safety improvement.

What are the risks of manual treatment of the spine? A scoping review for clinicians.

Background: Communicating to patients the risks of manual treatment to the spine is an important, but challenging element of informed consent. This scoping review aimed to characterise and summarise the available literature on risks and to describe implications for clinical practice and research.

Method: A methodological framework for scoping reviews was followed.

How do chiropractors manage clinical risk? A questionnaire study.

Background: The literature on chiropractic safety tends to focus on adverse events and little is known about how chiropractors ensure safety and manage risk in the course of their daily practice. The purpose of this study was to investigate how chiropractors manage potentially risky clinical scenarios. We also sought to establish how chiropractors perceive the safety climate in their workplace and thus whether there is an observable culture of safety within the profession.

When is a polyclinic not a polyclinic?

To appease concerns over the future of primary care, will we see polyclinics rebranded as health centres? investigates

A636P testing in Ashkenazi Jews.

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited colorectal cancer syndrome attributable to mutations in one of several DNA mismatch repair genes, most commonly MLH1 and MSH2 . In certain populations, founder mutations account for a substantial portion of HNPCC. In this report we summarize the literature and our personal experience testing for a specific founder mutation in the Ashkenazi Jewish population, MSH2*1906G > C , also known as A636P.

A636P is associated with early-onset colon cancer in Ashkenazi Jews.

Background: Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatous polyposis from mutations of APC, or hereditary nonpolyposis colorectal cancer, resulting from mutations of MSH2, MLH1, MSH6, or other genes. Previously, we described a rare founder mutation MSH2*1906C > G in Ashkenazi Jews that was found in 8 of 1,345 individuals (0.6%) of Ashkenazi descent with colorectal cancer.

Distance learning to support postgraduate training in obstetrics and gynaecology.

A number of major distance learning programmes have been launched by the medical Royal Colleges for the purposes of training and/or continuing medical education. The most recent is 'StratOG', a modular programme published by the Royal College of Obstetricians and Gynaecologists (RCOG) and aimed primarily at candidates for the part 2 RCOG Membership examination.