Publications by authors named "Rob F Lammers"
Article Synopsis
- GBA2 is an enzyme that plays a critical role in breaking down glucosylceramide and has been linked to diseases like Sandhoff and Niemann-Pick type C, as well as parkinsonism.
- Researchers have developed a specific activity-based probe (ABP) to study GBA2, which shows promise as a tool for visualizing and understanding this enzyme's function and location within cells.
- The probe, β-d-arabinofuranosyl cyclitol aziridine, selectively binds to GBA2, allowing researchers to distinguish its subcellular localization from that of another enzyme, GBA1, and suggests a pathway for developing new GBA2 inhibitors for future clinical use.
