Publications by authors named "Rob Brownstone"
Article Synopsis
- The study explores how neural circuits in mice adapt during early stages of progressive motoneuron degeneration, which helps maintain normal movement despite cell loss.
- It finds that, early on, a specific pre-motor circuit's neurotransmission is significantly reduced due to decreased density of glycine receptors, but this impairment is not widespread across all spinal inhibitory circuits.
- Later stages of the disease show recovery in neurotransmission and increased excitation of motoneurons, indicating that spinal microcircuits undergo specific compensatory changes that help preserve muscle force output.
In many neurological conditions, early-stage neural circuit adaption can preserve relatively normal behaviour. In some diseases, spinal motoneurons progressively degenerate yet movement is initially preserved. We therefore investigated whether these neurons and associated microcircuits adapt in a mouse model of progressive motoneuron degeneration.
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