Adjunctive use of hyaluronic acid in non-surgical periodontal therapy: A systematic review and meta-analysis.

Introduction And Objectives: Clinical studies have shown that adjunctive use of hyaluronic acid (HA) as part of non-surgical periodontal treatment (NSPT) has led to favourable clinical outcomes. However, no systematic review and meta-analysis has been carried out recently and technical and patient factors have not been previously explored. Therefore, the aim of this systematic review and meta-analysis is to evaluate the clinical effects of topical- HA as an adjunct to NSPT on probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BoP) in periodontitis patients.

The efficacy of salivary Histatin-1 protein in wound closure of nicotine treated human periodontal ligament fibroblast cells - In vitro study.

Objectives: The aims of this study were to investigate the efficacy of Histatin-1 in wound closure as well as effects on gene expression of nicotine-treated human Periodontal Ligament Fibroblast cells (HPDL) in vitro.

Design: HPDL grown in 2.5% culture medium treated with 10 ng/ml Histatin - 1 in the presence/absence of 0.

Cancer immunotherapy resistance: The impact of microbiome-derived short-chain fatty acids and other emerging metabolites.

The landscape of cancer therapy has undergone dramatic changes over the past decade. Immune checkpoint inhibitors (ICIs) among various cancer immunotherapies have transformed the treatment paradigm for cancer therapy and improved the survival of patients. Nevertheless, oncologists are faced with key challenges that need to be overcome, such as the unpredictability of patient response to these therapies and the many immune-related adverse effects (irAEs).