Press-Coated Aceclofenac Tablets for Pulsatile Drug Delivery: Formulation and In Vitro Evaluations.

The symptoms of some diseases show circadian rhythms, such as the morning stiffness associated with pain at the time of awakening in rheumatoid arthritis. Therapy for such diseases doesn't require immediate release or sustained release of medicament. In such therapies, pulsatile drug release is more suitable with a programmed drug release.

Antibiotic principles from a Streptomyces species and their sub-acute toxicity studies on hepatic, renal and haemopoietic system of rats.

Two promising antibiotics, JF-A and JF-B were isolated from the chloroform extract of a Banglaeshi Streptomyces strain. The mean zones of inhibition produced by the chloroform extract (400 microg/disc), JF-A (200 microg/disc) and JF-B (200 microg/disc) against 19 pathogenic bacteria were found to be 9-50, 12-38 and 10-41 mm while those produced by a standard antibiotic, kanamycin were 11-40 mm at 30 microg/disc. MICs of JF-A and JF-B were determined to be 64 microg/ml against Bacillus subtilis and 64 and 128 microg/ml against Shigella sonnei, respectively.