Publications by authors named "Rizwana Mohseni"
Article Synopsis
- Metabolic dysfunction-associated steatohepatitis is a severe form of nonalcoholic fatty liver disease linked to insulin resistance and inflammation, leading to major liver issues and transplants.
- A clinical trial tested the safety of oral insulin in patients with this liver disease and type 2 diabetes, comparing it to a placebo over 12 weeks.
- The findings showed insulin was safe and reduced liver fat and fibrosis more effectively than the placebo, suggesting it may help in treating this condition.
Article Synopsis
- The study aimed to assess the effectiveness of a combination treatment of casirivimab and imdevimab in preventing the development of symptomatic COVID-19 from early asymptomatic SARS-CoV-2 infections.
- Conducted as a phase 3 trial with 314 participants who were close contacts of infected individuals, this randomized, double-blind study compared the treatment group to a placebo group.
- Results showed that the treatment significantly reduced the progression to symptomatic disease, with 29% of treated participants developing symptoms compared to 42% in the placebo group, indicating a promising avenue for treating asymptomatic infections.
Background: REGEN-COV (previously known as REGN-COV2), a combination of the monoclonal antibodies casirivimab and imdevimab, has been shown to markedly reduce the risk of hospitalization or death among high-risk persons with coronavirus disease 2019 (Covid-19). Whether subcutaneous REGEN-COV prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent Covid-19 in persons at high risk for infection because of household exposure to a person with SARS-CoV-2 infection is unknown.
Methods: We randomly assigned, in a 1:1 ratio, participants (≥12 years of age) who were enrolled within 96 hours after a household contact received a diagnosis of SARS-CoV-2 infection to receive a total dose of 1200 mg of REGEN-COV or matching placebo administered by means of subcutaneous injection.
Background & Aims: Increased de novo lipogenesis creates excess intrahepatic fat and lipotoxins, propagating liver damage in nonalcoholic steatohepatitis. TVB-2640, a fatty acid synthase inhibitor, was designed to reduce excess liver fat and directly inhibit inflammatory and fibrogenic pathways. We assessed the safety and efficacy of TVB-2640 in patients with nonalcoholic steatohepatitis in the United States.
View Article and Find Full Text PDFBackground: Casirivimab and imdevimab (REGEN-COV™) markedly reduces risk of hospitalization or death in high-risk individuals with Covid-19. Here we explore the possibility that subcutaneous REGEN-COV prevents SARS-CoV-2 infection and subsequent Covid-19 in individuals at high risk of contracting SARS-CoV-2 by close exposure in a household with a documented SARS-CoV-2-infected individual.
Methods: Individuals ≥12 years were enrolled within 96 hours of a household contact being diagnosed with SARS-CoV-2 and randomized 1:1 to receive 1200 mg REGEN-COV or placebo via subcutaneous injection.
Importance: Easy-to-administer antiviral treatments may be used to prevent progression from asymptomatic infection to COVID-19 and to reduce viral carriage.
Objective: Evaluate the efficacy and safety of subcutaneous casirivimab and imdevimab antibody combination (REGEN-COV) to prevent progression from early asymptomatic SARS-CoV-2 infection to COVID-19.
Design: Randomized, double-blind, placebo-controlled, phase 3 study that enrolled asymptomatic close contacts living with a SARS-CoV-2-infected household member (index case).
Background And Aims: NAFLD is characterized by insulin resistance and dysregulated lipid and glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor-α/γ agonist, improves insulin sensitivity, and lipid and glycemic parameters. Saroglitazar improved NASH histology in animal studies.
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