Evaluation of Gingival Depigmentation Using Different Surgical Techniques and Prevention of Repigmentation With Vitamin C: A Clinical Study.

Background Gingival depigmentation is a cosmetic periodontal plastic surgical procedure for removing or reducing unesthetic melanin hyperpigmentation-the reappearance of melanin pigmentation after gingival depigmentation has been reported. Vitamin C has been routinely used for the management of hyperpigmentation in dermatology. However, very few studies have been conducted on the use of Vitamin C for the management of gingival hyperpigmentation.

Estimation of Tyrosinase-Related Protein 1 (TRP-1) Gene Expression in Human Gingiva and Its Correlation With Gingival Melanin Hyperpigmentation: A Pilot Study.

Background Melanin synthesis in humans relies on the activity of the tyrosinase enzyme, along with tyrosinase-related proteins 1 and 2 (TRP-1 and TRP-2). TRP-1 functions as a 5,6-dihydroxyindole-2-carboxylic acid oxidase and plays a crucial role in activating and stabilizing tyrosinase, as well as in melanosome synthesis. However, TRP-1 gene expression in human gingiva has not been explored.

Association of periodontal disease with oral lichen planus: A systematic review and meta analysis.

Background: Gingival lesions in oral lichen planus can indirectly increase the risk of plaque-induced periodontal disease when symptoms associated with such lesions hamper the proper oral hygiene maintenance by the patients and can increase the risk of periodontal tissue destruction. This systematic review analyses the existing evidence on the association between oral lichen planus and periodontal disease.

Aim: This systematic review of case-control studies aimed to analyse the association between periodontal disease and oral lichen planus.

Expression of tyrosinase gene in gingiva: A pilot study.

Background: Melanin is the predominant pigment responsible for the color of skin, hair, iris of eyes, and oral mucosa. Tyrosinase (TYR) is the key enzyme involved in melanin synthesis. Studies in dermatology have shown a positive correlation between TYR enzyme levels and melanin pigmentation of the skin.

The effect of Vitamin C on melanin pigmentation - A systematic review.

Vitamin C, also known as ascorbic acid, is used as a treatment modality in depigmentation of hyperpigmented spots on the skin and gingiva. This systematic review discusses the studies conducted to assess the effect of Vitamin C on melanin pigmentation. The primary objective was to evaluate the effect of Vitamin C on melanin pigmentation.