Control of disseminated scedosporium prolificans infection and endophthalmitis.

Purpose: To report a case of endogenous endophthalmitis as the presenting sign of a disseminated Scedosporium prolificans infection.

Methods: A 38-year-old woman on chronic immunosuppressive treatment for a cardiac transplant was examined for blurry vision in her right eye. Dilated fundus examination in the right eye revealed a large serous retinal detachment with subretinal cream-colored masses.

Comparison of clinically relevant findings from high-speed fourier-domain and conventional time-domain optical coherence tomography.

Purpose: To compare the sensitivities of high-speed Fourier-domain optical coherence tomography (FD-OCT) and conventional time-domain (TD) OCT for the detection of clinical findings important in the management of common vitreoretinal disorders.

Design: Prospective, observational study.

Methods: FD-OCT scans (128 B scans x 512 A scans) were obtained using a prototype instrument (3 D-OCT; Topcon, Tokyo, Japan) in 50 eyes of 28 consecutive patients undergoing conventional high-resolution (6 B scans x 512 A scans) TD-OCT imaging (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA).

Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy.

Purpose: To report an unusual case of paraneoplastic pseudovitelliform lesions associated with melanoma-associated retinopathy (MAR).

Design: Observational case report.

Methods: Retrospective review of the ophthalmic examination, fundus photography, fluorescein angiography, electroretinogram (ERG), and optical coherence tomography (OCT) of a patient with MAR.

Expression of beta-carotene 15,15' monooxygenase in retina and RPE-choroid.

Purpose: Beta-carotene 15,15' monooxygenase (beta-CM) catalyzes the central cleavage of beta-carotene to all-trans-retinal, the first step in vitamin A synthesis. This study was conducted to determine the expression of beta-CM in the mammalian retina and RPE, to assess its relevance in carotenoid-retinoid metabolism in the retina and RPE.

Methods: RT-PCR was used to detect expression of beta-CM mRNA in the retina and RPE-choroid of the mouse, cow, human, and monkey and in RPE cells and other cell lines.