Beyond the needle: How nonsurgical management transforms foot and ankle ability in male footballers with posterior ankle impingement- a longitudinal study.

Purpose: Posterior ankle Impingement (PAI) is a condition commonly affecting athletes and individuals engaged in activities involving repetitive ankle plantar flexion. This study aimed to evaluate the impact of nonsurgical management, excluding corticosteroid injections, on the functional outcomes of football players diagnosed with PAI.

Materials And Methods: Twenty male football Players between age group of 18-30 years, clinically diagnosed of PAI, were included in this longitudinal study.

Beeswax-based nanoconstructs enriched dual responsive hydrogel for diabetic foot ulcers in streptozotocin-induced diabetic rats.

Diabetic foot ulcer (DFU) is a complicated pathophysiological process, and there is now no recognized treatment. Hyperglycemia, neuropathy, impaired angiogenesis, reactive oxygen species, and advanced glycation end products construct the distinctive wound environment of diabetic wounds. This study aimed to develop naringenin-ferulic acid beeswax-based nanoconstructs enriched dual-responsive hydrogel (NAR-FA NLC HG) for topical application for DFU.

Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation.

Breast cancer is caused by aberrant breast cells that proliferate and develop into tumors. Tumors have the potential to spread throughout the body and become lethal if ignored. Metastasis is the process by which invasive tumors move to neighboring lymph nodes or other organs.

Improving Quality of Life in Underserved Communities: A Case from Humanity Initiative's Student-Led Clinics.

Using the case study of a 12-year-old girl diagnosed with complex congenital heart disease at a student-led clinic (SLC) organized by Humanity Initiative (HI) in Karachi, the paper highlights the effectiveness of SLCs in providing accessible and comprehensive healthcare services. The article contributes to existing literature by demonstrating the practical benefits of SLCs in a real-world setting, particularly in resource-limited environments. It underscores the potential of SLCs not only to improve community health but also to enhance medical education by providing students with hands-on experience and fostering a sense of social responsibility.

Point-of-Care Ultrasound for Diagnosis of Mandibular Fracture in a Pediatric Patient: A Case Report.

Point-of-care ultrasound has been shown to be effective in diagnosing many types of fractures, including nasal fractures, but it is not commonly used in pediatrics to diagnose mandibular fractures. We describe a case of a mandibular fracture diagnosed by point-of-care ultrasound in the pediatric emergency department. Additional studies are needed in the pediatric population to determine if point-of-care ultrasound can diagnose mandibular fracture rapidly and accurately, expediting diagnosis and potentially minimizing exposure to ionizing radiation in patients with no point-of-care ultrasound evidence of mandibular fracture.

Cross-cultural adaptation and validation of an Urdu version of the Vaccine Attitudes Examination (VAX-U) scale.

Background: Martin and Petrie developed the Vaccine Attitudes Examination (VAX) scale with an aim to document general vaccination attitudes. Vaccine acceptance plays an important role in curbing COVID-19 infections. Thus, it was important to assess vaccination attitudes of Pakistani people towards novel COVID-19 vaccines.

Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial.

Transcranial direct current stimulation (tDCS) has been proposed as a new treatment in major depressive disorder (MDD). This is a fully remote, multisite, double-blind, placebo-controlled, randomized superiority trial of 10-week home-based tDCS in MDD. Participants were 18 years or older, with MDD in current depressive episode of at least moderate severity as measured using the Hamilton Depression Rating Scale (mean = 19.

Engineering anisotropic tissue analogues: harnessing synergistic potential of extrusion-based bioprinting and extracellular matrix-based bioink.

In the realm of tissue engineering, replicating the intricate alignment of cells and the extracellular matrix (ECM) found in native tissue has long been a challenge. Most recent studies have relied on complex multi-step processes to approximate native tissue alignment. To address this challenge, we introduce a novel, single-step method for constructing highly aligned fibrous structures within multi-modular three-dimensional conglomerates.

Design and development of symmetric aromatic bischalcogenide-based photocatalysts for water treatment application: a concise study of diphenyl diselenide polypyrrole nanocatalysis.

Dopant engineering can be a very selective approach in designing hybrid materials. Incorporating the required functionality in a dopant effectively modulates its properties towards aimed applications. Consequently, this work through a comparative study envisaged the incorporation of chalcogenides (S, Se, and Te) in a biphenyl motif based on the analysis of major photocatalytic descriptors.

Enhancing physical attributes and performance in badminton players: efficacy of backward walking training on treadmill.

Background: Badminton, a dynamic sport, demands players to display exceptional physical attributes such as agility, core stability, and reaction time. Backward walking training on a treadmill has garnered attention for its potential to enhance physical attributes and optimize performance in athletes while minimizing the risk of injuries.

Objective: By investigating the efficacy of this novel approach, we aim to provide valuable insights to optimize training regimens and contribute to the advancement of sports science in badminton.

Improving Access to Patient-Focused, Decentralized Clinical Trials Requires Streamlined Regulatory Requirements: An ASCO Research Statement.

Strategies to bring clinical trials closer to patients gained momentum during the COVID-19 pandemic, enabling more participants to receive treatment and/or testing in their local communities. Incorporation of decentralized trial elements presents both opportunities and challenges, spanning regulatory, technical, and operational aspects. This ASCO research statement includes timely consensus-driven recommendations and a call for engagement of all research stakeholders.

Gamma-Irradiated Gum Arabic Grafted with 2-Hydroxyethyl Methacrylate: A Novel Superabsorbent Polymer for Controlled Folic Acid Release.

This study explores the synthesis and characterization of superabsorbent hydrogels derived from chemically modified gum Arabic, designed for controlled folic acid release. The synthesis involves a two-step process: carboxymethylation followed by grafting with 2-hydroxyethyl methacrylate via gamma irradiation. The resulting hydrogels exhibit enhanced mechanical strength and controlled diffusivity, essential for nutrient delivery systems.

Modular access to sulfur substituted analogues of isocytosine photoredox catalysis.

A photoredox approach for synthesizing sulfur-substituted analogues of isocytosine coupling of modular phenyl propargyl chloride with thiourea has been reported. The resulting product with an amine group was found amenable to various late-stage modifications, providing access to a broad range of sulfur-containing isocytosine derivatives.

Design and Implementation of Brief Interventions to Address Noncommunicable Diseases in Uzbekistan.

In Uzbekistan, NCDs, including cardiovascular diseases, cancer, and diabetes, accounted for over 80% of mortality in 2019. In 2021, national stakeholders, in conjunction with the World Health Organization, identified brief interventions (BIs) to implement in primary health care settings to change unhealthy behaviors and reduce the burden of NCDs in the country. BIs consist of a validated set of questions to identify and measure NCD behavioral risk factors and a short conversation with patients/clients about their behavior, as well as the provision of a referral opportunity for further in-depth counseling or treatment if needed.

Implementation of School Nutrition Policies to Address Noncommunicable Diseases in Uzbekistan and Kyrgyzstan.

Noncommunicable diseases (NCDs), including cardiovascular diseases, cancer, and diabetes, account for over 80% of mortality in Uzbekistan and Kyrgyzstan in 2019, and unhealthy dietary behaviors are a major risk factor for NCDs in both countries. In 2021, national stakeholders, in consultation with the World Health Organization, identified school nutrition policies (SNPs) as a major approach to reducing the burden of NCDs in both countries. The SNPs included interventions implemented through a multistakeholder and multisectoral arrangement that aimed to improve the health and nutrition status of children and young people by providing healthy food/beverages and restricting unhealthy foods or beverages in schools.

Point-of-Care Ultrasound Evaluation of Pediatric Osteomyelitis in the Emergency Department: A Case Series.

Musculoskeletal and soft tissue complaints commonly present to the pediatric emergency department and literature supports the use point-of-care ultrasound (POCUS) in the diagnosis of these complaints. The diagnosis of osteomyelitis typically involves laboratory testing with inflammatory biomarkers, imaging with x-ray, and often magnetic resonance imaging with test results often not immediately available. We report a case series of children initially evaluated with POCUS for osteomyelitis.

Unknotting tech neck by breaking the cycle of pain and disability: Comparing the impact of instrument assisted soft tissue mobilization on specific muscles and superficial back arm line.

Background: Computer professionals often develop a forward head posture due to prolonged hours of computer use, leading to neck pain. Instrument-assisted soft tissue mobilization (IASTM), an advanced technique for treating myofascial trigger points, has become increasingly popular for addressing these musculoskeletal issues.

Objectives: The study aimed to compare the effectiveness of IASTM mobilization on SBAL (superficial back arm line) and SM(specific muscles-upper trapezius, levator scapulae, and sternocleidomastoid) in managing chronic neck pain among computer professionals.

Adsorptive avidity of Prussian blue polypyrrole nanocomposite for elimination of water contaminants: a case study of malachite green and isoniazid.

Persistent water contaminants include a variety of substances that evade natural cleaning processes posing severe risks to ecosystems. Their adsorptive elimination is a key approach to safer attenuation. Herein we present the design and development of Prussian blue incorporated polypyrrole (PPY/PB) hybrid nanocomposite as a high-performance adsorbent for the elimination of malachite green (M.

Regional variations in antimicrobial susceptibility of community-acquired uropathogenic in India: Findings of a multicentric study highlighting the importance of local antibiograms.

Objectives: Evidence-based prescribing is essential to optimize patient outcomes in cystitis. This requires knowledge of local antibiotic resistance rates. Diagnostic and Antimicrobial Stewardship (DASH) to Protect Antibiotics (https://dashuti.

Effects of pain education on disability, pain, quality of life, and self-efficacy in chronic low back pain: A randomized controlled trial.

Background: Low back pain stands as a prevalent contributor to pain-related disability on a global scale. In addressing chronic low back pain (CLBP), there is a growing emphasis on incorporating psychological strategies into the management process. Among these, pain education interventions strive to reshape pain beliefs and mitigate the perceived threat of pain.

Assessing muscle energy technique and foam roller self-myofascial release for low back pain management in two-wheeler riders.

Pain in the lower back is a major concern in today's era due to prolonged sitting in two-wheeler riders, mainly due to hamstring tightness. It also creates physical disability and impairment in activities of daily living. The study aimed to compare the efficacy of muscle energy technique (MET) and self-myofascial release (SMFR) using the foam roller on hamstring flexibility, dynamic balance, and physical disability amongst two-wheeler riders with chronic low back pain (LBP).

Antimicrobial resistance pattern of Uro-Pathogens emphasizing non-lactose fermenting gram negative bacilli.

Objectives: To identify various species of non-lactose fermenting gram-negative bacilli involved in urinary tract infections, and to determine their antimicrobial resistance pattern.

Methods: The retrospective, descriptive, cross-sectional study was conducted from January 1 to April 1, 2022, at the Dow University of Health Sciences, Karachi, and comprised data from the institutional diagnostic laboratory that was related to urine samples regardless of age and gender from January 1, 2020, to December 31, 2021. Data was analysed using SPSS version 25.