Publications by authors named "Rizqi Amanda Nabilah"
Article Synopsis
- - The study investigates how variations in the ABCB1 gene (which affects clopidogrel absorption) influence the response to clopidogrel in ischemic stroke patients, assessing the impact of two specific polymorphisms: C3435T and C1236T.
- - In a sample of 124 patients, the results show that about 12.9% were non-responsive to clopidogrel, while 41.9% faced a higher risk of bleeding, particularly those with the C1236T homozygote wildtype genotype, which increased bleeding risk by 3.76 times.
- - The research found that the most prevalent genotype for ABCB1 C3435T was heterozygote
Objective: Clopidogrel is a common antiplatelet used as secondary prevention of ischemic stroke, known to have better efficacy than aspirin, with a equivalent safety profile. However, clopidogrel resistance is not uncommon but has not been widely studied in Asia. This study will further assess clopidogrel resistance and its risk factors.
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