Management of acute bleeding in a patient with congenital afibrinogenaemia.

Congenital afibrinogenaemia is a rare bleeding disorder characterized by absence of fibrinogen and varying bleeding tendency. Treatment with fibrinogen concentrates is considered to be the best choice for afibrinogenaemic patients who experience bleeding. We report the case of a 22-year-old Greek patient who presented with large muscular haematomas and was treated with fibrinogen concentrates.

Pegylated IFN-alpha 2b added to ongoing lamivudine therapy in patients with lamivudine-resistant chronic hepatitis B.

Aim: To investigate the role of pegylated-interferon (IFN) alpha-2b in the management of patients with lamivudine-resistant chronic hepatitis B.

Methods: Twenty consecutive anti-HBe positive patients were treated with pegylated IFN alpha-2b (100 mug sc once weekly) for 12 mo. There was no interruption in lamivudine therapy.

Prescription of medications by primary care physicians in the light of asthma guidelines.

The purpose of this study was the evaluation of the extent of dissemination of asthma guidelines among primary health care physicians in Greece. Sixty-five of 80 primary care physicians (response rate 80.2%) answered a questionnaire about asthma morbidity, manner of choice of treatment and asthma management plans.