Expansion limits of meshed split-thickness skin grafts.

Split-thickness skin grafts are widely used to treat chronic wounds. Procedure design requires surgeons to predict how much a patch of the patient's own skin expands when it is meshed with rows of slits and stretched over a larger wound area. Accurate prediction of graft expansion remains a challenge, with current models overestimating the actual expansion, leading to suboptimal outcomes.

A Curated Graphene Quantum Dot-Porphyrin-Based Photosensitizer for Effective Singlet Oxygen Generation through Energy Transfer.

Porphyrin-based photosensitizers are proven generators of reactive oxygen species (ROS), such as singlet oxygen, and used as anti-cancer therapeutic agents. However, most of these compounds suffer from potential drawbacks due to limited photostability, hydrophobicity, aggregation propensity, and low cellular uptake. Ultrasmall fluorescent graphene quantum dots (GQDs) have emerged as the next-generation carriers for drugs and have gained reputation in the pharmaceutical domain.

Graphene Quantum Dot Assisted Translocation of Daunomycin through an Ordered Lipid Membrane: A Study by Fluorescence Lifetime Imaging Microscopy and Resonance Energy Transfer.

Daunomycin (DN) is a well-known chemotherapy drug frequently used in treating acute myeloid and lymphoblastic leukemia. It needs to be delivered to the therapeutic target by a delivering agent that beats the blood-brain barrier. DN is known to be specifically located at the membrane surface and scantly to the bilayer.

Daunomycin delivery by ultrasmall graphene quantum dots to DNA duplexes: understanding the dynamics by resonance energy transfer.

Daunomycin (DN) is a natural product isolated from Streptomyces and it is widely used as a chemotherapeutic medication because of its antitumour properties. It is an anthracycline antibiotic that inhibits virus multiplication and shows activity against acute leukemia. This drug is either injected into a vein of the subject or typically delivered to cellular nuclei by polymeric or metallic nanoparticles and liposomal or proteinous substrates.

β-Cyclodextrin Encapsulated Coumarin 6 on Graphene Oxide Nanosheets: Impact on Ground-State Electron Transfer and Excited-State Energy Transfer.

We report a unique phenomenon of physical adsorption of coumarin 6-β-cyclodextrin (C6-β-CD) inclusion nanostructures on graphene oxide (GO) nanosheets, thus inducing ground-state electron transfer from the C6-β-CD composite to GO. On excitation, the C6-β-CD composite initially transfers energy to the attached GO surface and subsequently collides with similar C6-β-CD@GO adducts leading to dynamic quenching of energy. The ground-state two-electron transfer process has been confirmed by cyclic voltammetry in aqueous medium, whereas the excited-state processes were inferred from steady-state and time-resolved fluorescence spectroscopy.