Publications by authors named "Riya Shivgotra"
Article Synopsis
- * SLNs, created using biodegradable lipids, showed better skin deposition and retention of LCZ compared to commercial formulations, despite releasing less of the drug in ex-vivo tests.
- * The findings suggest that SLNs enhance the solubility and efficacy of LCZ, allowing for prolonged antifungal action at the infection site while minimizing systemic circulation and skin irritation risks.
This study aimed to develop a propellant-free topical spray formulation of Etodolac (BCS-II), a potent NSAID, which could be beneficial in the medical field for the effective treatment of pain and inflammation conditions. The developed novel propellant-free spray formulation is user-friendly, cost-effective, propellant-free, eco-friendly, enhances the penetration of Etodolac through the skin, and has a quick onset of action. Various formulations were developed by adjusting the concentrations of different components, including lecithin, buffering agents, film-forming agents, plasticizers, and permeation enhancers.
View Article and Find Full Text PDFScalp psoriasis is a common manifestation of psoriasis that significantly impacts a patient's quality of life. About 80% of cases of psoriasis involve the scalp, making it the most frequently affected area of the body. The treatment of scalp psoriasis is particularly crucial because of its hard-to-treat nature and substantial adverse impacts on overall well-being.
View Article and Find Full Text PDFTotal Parenteral Nutrition (TPN) is a method of providing nutrients directly into the bloodstream for individuals who are unable to meet their nutritional needs through the normal digestive process or gastrointestinal system. It provides macronutrients and micronutrients in a single container, reducing handling and contamination risks and making it more cost-effective. TPN has the potential to be used as a drug delivery system, with applications in combination therapies, personalized medicine, and integrating advanced technologies.
View Article and Find Full Text PDFThis article explores the significant impact of artificial intelligence (AI) and machine learning (ML) on the pharmaceutical industry, which has transformed the drug development process. AI and ML technologies provide powerful tools for analysis, decision-making, and prediction by simplifying complex procedures from drug design to formulation design. These techniques could potentially speed up the development of better medications and drug development processes, improving the lives of millions of people.
View Article and Find Full Text PDFArticle Synopsis
- Over 150 million people suffer from significant fungal diseases, exacerbated by the rise of immunocompromised patients and COVID-19 infections, particularly highlighting pulmonary aspergillosis and other invasive fungi.
- The most common fungal pathogen, Candida spp., contributes to around one billion infections annually, underscoring the critical need for improved recognition and treatment of these infections, which have high morbidity and mortality rates.
- The study explores novel antifungal strategies, including nanotechnology and immunotherapy, aiming to develop more effective, safer, and cost-efficient treatments to combat the challenges presented by conventional antifungal therapies.