[The mechanisms of fucoidan action on human complement].

The action of fucoidan (a sulfated polysaccharide) on human serum complement has been under study. Fucoidan inhibited the classical pathway of complement activation up to the complete arrest of the complement-dependent hemolysis achieved at the polysaccharide concentration higher than 200-250 mg per 1 ml of human serum. The classical pathway inhibition by fucoidan seems to be due to the binding to subcomponent C1q.

[Modification of proteolytic complement cascade after treatment with exogenous heparin].

The influence of heparin therapeutic concentrations (0.25-10 U/ml) on the kinetic indices of human serum complement activity has been studied. An acceleration of complement-dependent lysis of rabbit erythrocytes via alternative complement pathway was found at low (0.

[Turbidimetric analysis of fibrin polymerization in the plasma].

The turbidimetrical assay of thrombin-induced plasma coagulation provides a possibility to estimate both stages of fibrinogen-fibrin conversion. The initial one, which proceeds without any change of turbidity, reflects the process of protofibril formation, and the second stage of lateral aggregation, is characterized by the rise of turbidity. The influence of heparin, alga (Laminaria digitata) aqueons extracts, and collagenase on the indices of the turbidity-time curve has been studied.

[Activity of the complement system in blood serum of dogs after treatment of acute necrotic pancreatitis with boiled pancreatic juice].

The investigations were conducted on 14 dogs. To assess the blood serum complement system, the erythrocyte lytic rate of a rabbit (RE) and a sheep (SE), the hemolytic capacity of the complement system against rabbit (RH) and sheep (SH) was measured. In acute necrotic pancreatitis, no changes in SE and SH were revealed either in the control and experimental animals.

[Concentration-functional interrelationships in the human alternative complement activation pathway].

The dependence of the rate of human complement mediated lysis of rabbit erythrocytes on concentrations of factors B and D of the alternative pathway is characterized by saturation kinetics. At low B and D concentrations no lysis occurs until certain "threshold" concentrations of the respective factor are reached. The type of dependence of the hemolysis rates on the C3 concentration is wavelike, i.

[The action of karbogal on the complement system under model conditions and in an animal experiment].

The influence of dimethylperfluorocyclohexane (carbogal) on the hemolytic activity of human blood serum complement was studied in vitro. It has been show that different effects of carbogol on the complement depend on the serum lipid composition. Endotracheal administration of carbogal to rats results in a significant reduction of complement activity in the animal's blood.

[Assessment of patients' condition by noninvasive methods of examination in the follow-up after Fontan's operation in atresia of the right atrioventricular ostium].

The article discusses the results of using noninvasive methods to study the condition of patients (20) in late-term periods after Fonten's operation in atresia of the right atrioventricular orifice. All patients were subjected to physical examination, electro-, phono- and echocardiography, radiological examination, radioisotope scintigraphy, and left ventriculography. Most patients change to functional class I in the late-term periods after the operation.

[The effect of plasmin on complement in human blood serum].

Plasma exhibited the dose-dependent inactivating effect on human blood serum hemolytic complement both in classic and alternative pathways. Negative correlation (r = -0.8) was found between the rate of complement inactivation and content of C3 component.

[Structure and properties of the complement system proteinases].

Biochemical aspects of enzymes of the complement functioning are presented. Proteolytic, esterolytic and amidolytic characteristics of the complement components which are enzymes in their nature as well as the structure and properties of complex proteases of the activated complement are analyzed.

[Hypoplasia of the right ventricle with interatrial communication through the coronary sinus].

Isolated hypoplasia of the right ventricle is a rare congenital anomaly. The complex defect comprises also a communication between the atria in the form of an oval window or secondary atrial septal defect. The possibility of a communication between the atria via the coronary sinus having in such cases an additional orifice in the left atrium cannot be excluded.