Cytokine gene polymorphism in microscopic colitis association with the IL-6-174 GG genotype.

Objectives: Microscopic colitis (MC) is a chronic inflammatory disease with unknown pathogenesis. Very little is known about polymorphisms in the cytokine genes in MC. We have investigated the occurrence of well-characterized polymorphisms of interleukins (IL-6, IL-1β, IL-1 receptor antagonist, IL-10) and CD14 in MC.

Gastroduodenal mucosa in microscopic colitis.

Background: We have assessed gastroduodenal, endoscopical and histopathological findings in a series of patients with microscopic colitis (MC).

Methods: We studied 75 patients with MC, 27 with collagenous colitis (CC) and 48 with lymphocytic colitis (LC), and 60 controls. Data of endoscopical findings were collected and biopsies were assessed.

Human leucocyte antigen and TNFalpha polymorphism association in microscopic colitis.

Objectives: Coeliac disease (CD) is common in patients with microscopic colitis (MC). The human leucocyte antigen (HLA)-DR3-DQ2 haplotype is strongly associated with CD, and there is evidence for an association with MC. We analysed the genetic background of MC by assessing the haplotypes of HLA-DR3-DQ2 and HLA-DR4-DQ8.