Oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX-4) as salvage chemotherapy in patients with pretreated colorectal cancer.

Background: There are a few clinical trials of combination chemotherapy of oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX-4) in Japan, and its efficacy and safety have not been confirmed yet, especially clinical experience in patients with prior chemotherapy.

Purpose: To analyze the efficacy and safety of FOLFOX-4 in patients with colorectal cancer who received prior chemotherapy.

Patients And Methods: Twenty patients were treated with FOLFOX-4 beginning in April 2005.