Publications by authors named "Ritu Raj Patel"
Even though the genus Mycobacterium is a diverse group consisting of a majority of environmental bacteria known as non-tuberculous mycobacteria (NTM), it also contains some of the deadliest pathogens (Mycobacterium tuberculosis) in history associated with chronic disease called tuberculosis (TB). Formation of biofilm is one of the unique strategies employed by mycobacteria to enhance their ability to survive in hostile conditions. Biofilm formation by Mycobacterium species is an emerging area of research with significant implications for understanding its pathogenesis and treatment of related infections, specifically TB.
View Article and Find Full Text PDFArticle Synopsis
- The rise of multidrug-resistant mycobacteria poses a serious challenge in treating tuberculosis, leading to treatment failures and reliance on more toxic, expensive medications.
- This study investigates the use of green-synthesized silver nanoparticles (AgNPs) and their polyethylene glycol encapsulated version (PEG-AgNPs) as potential novel antimicrobials, demonstrating that PEG-AgNPs have better stability and enhanced anti-mycobacterial activity.
- Characterization techniques revealed the uniform size and stability of PEG-AgNPs, and their effectiveness was shown through increased cell wall permeability and significant biofilm inhibition, along with a lack of toxicity towards human red blood cells.