Hydride Transfer-Based CO Reduction Catalysis: Navigating Metal Hydride to Organic Hydride in the Catalytic Loop.

ConspectusThe reductive conversion of carbon dioxide (CO) into value-added products is a process of immense importance. In the context of rising CO concentration in the atmosphere and the detrimental effects it is having on the biosphere, use of alternative fuels which can offer a low-carbon or carbon-neutral pathway for storage and utilization of low-carbon energy by maintaining the net atmospheric CO concentration might be a prospective solution. Among the wide variety of reduced products that can be obtained from CO, formic acid and formate salts are particularly important due to their ability to be used as an alternative fuel or a reversible hydrogen storage material.

A phosphine-free molecularly-defined Ni(II) complex in catalytic hydrogenation of CO.

The development of base metal catalysts capable of CO hydrogenation is a challenge and a necessity to progress from the scarce noble metal catalysts. In this regard, we report herein the first non-phosphine-based Ni complex, supported by a "carbazolato-bis-NHC" pincer ligand framework, for efficient catalytic hydrogenation of CO to formate. A tailored combination of the Ni complex as a catalyst, DBU as a base, and Zn(OAc) as an additive offered enhanced activity leading to a TON up to 5476 and an excellent yield up to 92% for the formate product from a reaction on ∼27 mmol scale.

Multiresponsive Nanoscale Self-Assembly of Azurin-Elastin-like Polypeptide Fusion Protein for Enhanced Prostate Cancer Therapy.

A fusion protein composed of a bacterial protein, azurin, having antineoplastic properties and a thermally responsive structural cationic elastin-like protein (ELP), is designed, cloned, expressed, and purified. A simple method of inverse transition cycle (ITC) is employed to purify the fusion protein azurin-ELP diblock copolymer (d-bc). The molecular weight of the azurin-ELP fusion protein is ∼32 kDa.

Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer.

Erythropoietin-producing hepatocellular (Eph) receptors and their ligands, ephrins, are the largest subfamily of receptor tyrosine kinases (RTKs) that have emerged as a new class of cancer biomarkers due to their aberrant expression in cancer progression. The activation of Eph receptors either due to their hyperexpression or via high affinity binding with their respective ephrin ligands initiates a cascade of signals that impacts cancer development and progression. In prostate cancer, the overexpression of the EphA6 receptor has been correlated with increased metastatic potential.

A magnetic field augmented ultra-thin layer chromatography coupled surface enhanced Raman spectroscopy separation of hemozoin from bacterial mixture.

Malaria is considered as one the most widespread disease with highest possibility of co-infection at all levels of the disease prognosis. Rapid detection and discrimination of malaria from other co-infections remains a challenge. Hemozoin is a metabolic biproduct of malaraia possessing paramagnetic property due to presence of iron at its centre.

Successful management of cervical dysgenesis: Case report and review.

Cervical agenesis or dysgenesis is a rare Mullerian anomaly that is usually associated with vaginal aplasia. A literature review revealed reports of 83 cases including ours, of which 57 (68.6%) presented with obstruction of the external OS, 11 (13.

Histopathological Changes in Placenta of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Infection and Maternal and Perinatal Outcome in COVID-19.

Background: Whether vertical transmission or placental pathology occurs after maternal infection during pregnancy remains unknown. There is a clear need for studies on the impact of COVID-19 on pregnancy outcome. A systemic inflammatory or hypercoagulable state may be the contributing factor for placental pathology.

An all-aqueous and phosphine-free integrated amine-assisted CO capture and catalytic conversion to formic acid.

A phosphine-free Ir(III)-NHC-based efficient catalytic system is developed for integrated CO capture with tetramethylguanidine as a capturing agent and conversion to formate with H gas, conducting both the steps in water, affording product yield up to 85% and TON up to 19 171 in just 12 h. In the segment of "integrated CO-capture and conversion to formate", this system represents not only the first phosphine-free module, but also one of the few best known homogeneous catalysts.

MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.

Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal ganglion cells (RGC), which is a characteristic feature of glaucoma. However, association of MTHFR C677T with glaucoma has been controversial because of inconsistent results across association studies. Association between MTHFR C677T and glaucoma has not been reported in Indian population.