Publications by authors named "Rittik Bhati"
Article Synopsis
- This study investigates potential drug targets in a pathogenic bacterium commonly found in the gastrointestinal tract, which poses a risk of infections and has rising antibiotic resistance.
- Using a subtractive proteomics approach, the researchers identified essential proteins and metabolic pathways linked to both the pathogen and its host to reduce side effects of new treatments.
- The study highlights MurM, a key protein involved in bacterial cell wall synthesis, as a promising drug target and identified several lead candidates for further development to combat antibiotic resistance.
Article Synopsis
- Warfarin is a cardiovascular drug that interacts strongly with lysozyme, primarily through hydrophobic forces, with temperature increasing the degree of binding.
- Experimental results revealed that while low concentrations of warfarin don't affect lysozyme's secondary structure, higher concentrations can lead to partial unfolding.
- Computational methods, including molecular docking and dynamics, confirmed stable binding and structural changes in lysozyme induced by warfarin, emphasizing its role in hydrogen bonding without drastically altering protein conformation.
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the delivery system which can control the plasma levels of it.
View Article and Find Full Text PDFDue to the multifarious nature of cancer, finding a single definitive cure for this dreadful disease remains an elusive challenge. The dysregulation of the apoptotic pathway or programmed cell death, governed by the Bcl-2 family of proteins plays a crucial role in cancer development and progression. Bcl-B stands out as a unique anti-apoptotic protein from the Bcl-2 family that selectively binds to Bax which inhibits its pro-apoptotic function.
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