Evaluation of cardiac iron overload in transfusion-dependent adult marrow failure patients by magnetic resonance imaging.

We investigated magnetic resonance imaging T2-star (MRI-T2*) values and left ventricular ejection fraction (LVEF) in 7 adult patients with bone marrow failure with heavy transfusion to elucidate the correlation between cardiac iron overload and dysfunction. We demonstrated a positive correlation between the total volume of red blood cells (RBC) transfusion and ejection fraction. The normal T2* limit value, which represents cardiac siderosis, is probably 200 mL/kg RBC transfusion.