[A Case of Persistent Dysesthesia after Uneventful Spinal Anesthesia with Bupivacaine].

We report a case of persistent dysesthesia lasting over a year in a patient after uneventful spinal anes- thesia with bupivacaine. A 67-year-old woman received spinal anesthesia for transurethral resection of bladder tumor. The surgery was performed in lithotomy position taking 20 min.

[A case of advanced hepatocellular carcinoma with lung metastases and cirrhosis that responded to combination chemotherapy with interferon-alpha and 5-fluorouracil].

The prognosis for patients with hepatocellular carcinoma (HCC) with progressive liver cirrhosis or extrahepatic metastases remains dismal. We report a case of HCC with liver cirrhosis and lung metastases who had been treated successfully by combination chemotherapy of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha). A 67-year-old male with a history of hepatitis C, liver cirrhosis and HCC was hospitalized because of cough and dyspnea.

[Combination chemotherapy with hepatic arterial infusion of 5-fluorouracil (5-FU) and systemic irinotecan (CPT-11) in patients with unresectable liver metastases from colorectal cancer].

Purpose: Hepatic arterial infusion (HAI) chemotherapy for hepatic metastasis from colorectal cancer has higher response rates compared with systemic chemotherapy, but can not control extrahepatic lesions. So the combination chemotherapy with HAI plus systemic chemotherapy is expected. This study ascertained the efficacy and toxicity of combined chemotherapy with HAI plus systemic CPT-11.

[Colonic perforation in a patient treated with combination chemotherapy for recurrent ovarian clear cell adenocarcinoma].

Background: Colonic perforation due to colitis is a known and reported side effect of chemotherapy.

Case Report: A 53-year-old woman was treated with combination chemotherapy of irinotecan plus cisplatin for a recurrent ovarian clear cell adenocarcinoma. Steroid was also used for suspected interstitial pneumonia.

[A case of advanced esophageal cancer with suspected tracheoesophageal fistula that responded to chemoradiotherapy].

Chemoradiotherapy combined cisplatin, 5-FU and radiation was carried out in an advanced esophageal cancer with suspected tracheoesophageal fistula after insertion of an expandable metallic stent. Regression of the primary tumor was observed, and oral intake could be started. Chemoradiotherapy after insertion of the expandable metallic stent was useful in this case of advanced esophageal cancer with suspected tracheoesophageal fistula.

[A case of recurrent breast cancer complicated with pericardial effusions and cardiac tamponade].

A 56-year-old female with breast cancer after left partial mastectomy and subaxillary lymph node dissection was treated with adjuvant chemoradiotherapy. After one year left lung metastasis and malignant pleural effusion had resisted and progressed against several types of chemotherapy. Although combination chemotherapy of trastuzumab and vinorelbine was started, pericardial effusions progressed.

Distribution of immunoglobulin Fab fragment conjugated with HIV-1 REV peptide following intravenous administration in rats.

HIV-1 REV peptide (positions 34-50) is well-known as a cell-permeating peptide. In this study, we investigated the distribution of Fab fragment of immunoglobulin conjugated with REV peptide (REV-Fab) following intravenous administration in rats, and compared with those of the native Fab fragment (nFab). Radioiodinated REV-Fab or nFab ((125)I-REV-Fab or (125)I-nFab, respectively) was given in a single intravenous dose of 2 mg/kg (3 MBq/kg).

[Possible approaches to cancer chemotherapy in palliative care medicine].

We discussed our attitude, ideas, and treatment practices, and presented several problems concerning palliative chemotherapy under the palliative medical environment in patients with advanced cancer in our hospital. We thought that, in many cases, they could be given further chemotherapy. Because of the clear availability of so-called palliative therapy, these patients tend not to elect another chemotherapy using more effective anti-tumor agents in the name of "acceptance.