Invasive meningococcal isolates in South Africa have shown a consistent presence of serogroups B, C, W, and Y between 2016-2021, with an intermediate penicillin resistance rate of 16%.
A total of 585 invasive meningococcal disease cases were monitored, with phenotypic and genomic analyses revealing key serogroups and clonal complexes.
The increased penicillin intermediate resistance was linked to specific penA gene mosaics, indicating a concerning rise in antibiotic resistance among these bacteria compared to prior years.