Publications by authors named "Ritika Panwar"
Article Synopsis
- The study focuses on finding a cost-effective way to treat Urinary Bladder Cancer (UBC) by using a combination of disulfiram (DSF) and copper gluconate (Cu) alongside traditional chemotherapy in a mouse model.
- Male C57BL/6J mice were exposed to a chemical known to induce UBC, and their treatment included various drug combinations, with significant evaluations performed on tumor formation and molecular expressions.
- Results showed that the DSF-Cu combination significantly reduced tumor size and burden, lowered levels of specific cancer-related enzymes, and indicated enhanced autophagy, showing potential for improved treatment strategies in UBC.
Article Synopsis
- Mycophenolic acid is commonly used to treat lupus nephritis but has varying effects among individuals, prompting researchers to create a population pharmacokinetic (popPK) model and limited sampling strategy (LSS) for better drug monitoring in Indian patients.
- The study involved collecting blood samples from 51 patients at different times after taking the medication to analyze how their bodies process it and to find key factors affecting variability.
- The results showed that a 1-compartmental model was the best fit for the data, and the optimal LSS involving samples taken at 1, 2, and 4 hours postdose effectively estimated drug levels, improving therapeutic drug monitoring practices.
Tacrolimus is a narrow therapeutic index drug. As a result, regulatory agencies worldwide recommend stringent bioequivalence evaluation criteria for approval of generics. Despite this, the professional transplantation societies have raised concerns over the safety and efficacy of generic substitutions.
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