Publications by authors named "Riti Biswas"
Article Synopsis
- Current antibody design is inefficient, relying on methods like animal immunization or library screening rather than rational design.
- A specialized RFdiffusion network has been developed that can create custom antibodies that target specific epitopes effectively.
- Experimental results show successful binding of the designed antibodies to four relevant disease epitopes, validating the model's accuracy through structural analysis.
We are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision. Therefore, considering even a dozen such formats, in combination with hundreds of possible targets, can create confusion and increase the complexity of drug discovery.
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