Publications by authors named "Rithu Kumar"
Article Synopsis
- - Chromothripsis is a process where a single catastrophic event causes significant genomic rearrangements, but its variability across different tumor clones and response to treatments is not well understood.
- - This study investigates chromothripsis in p53-deficient medulloblastoma and neural stem cells, focusing on the genomic and transcriptomic changes involved.
- - The researchers analyze the order of genetic events, explore subclonal variation, and identify how chromothripsis influences cancer development, targeted therapies, and the fitness of neural progenitor cells.
Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor entities and linked with poor prognosis in some of these, such as Sonic Hedgehog medulloblastoma, neuroblastoma and osteosarcoma. Hence, there is a need for therapeutic strategies eliminating tumor cells with chromothripsis.
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