Publications by authors named "Ritesh Sanghvi"
The solubilization efficiency of N-methyl pyrrolidone (NMP) has been determined and compared to that of ethanol and propylene glycol for 13 poorly soluble drugs. NMP is found to be a more efficient solubilizer for all the drugs studied. The solubility enhancement as high as about 800-fold is obtained in 20% v/v NMP solution as compared to water.
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- Antalarmin, a stress inhibitor, has poor water solubility (less than 1 microg/mL) and a pK(a) of 5.0, prompting the investigation of various solubilization methods, including pH control and lipid-based systems.
- Four formulations aimed at a drug loading of 100 mg/mL were tested for oral administration, with three being aqueous solutions and one lipid-based formulation.
- The lipid-based formulation showed superior performance, maintaining stability in simulated intestinal fluid and achieving over 12-fold higher oral bioavailability compared to suspension formulations, making it the most effective option.
Estimation of drug precipitation upon dilution of pH-cosolvent solubilized formulations.
Chem Pharm Bull (Tokyo)
August 2007
This manuscript is a study of precipitation of insoluble drug upon dilution from the pH-cosolvent solubilized formulation with simulated blood fluid. An equation is developed to estimate drug precipitation upon dilution of combined pH-cosolvent solubilized formulations. This is an extension of a previous equation used for the estimation of drug precipitation from simple pH controlled formulations.
View Article and Find Full Text PDFAn equation is developed for estimating the precipitation that may occur upon diluting or injecting a (pH-)solubilized drug formulation. Since it is based on equilibrium, it is the worst case scenario for precipitation. This equation can be programmed in any commercially available spread sheet program such as Excel.
View Article and Find Full Text PDFThe solubility enhancement of 11 poorly soluble drugs by complexation using nicotinamide has been studied. The solubilization efficiency of nicotinamide has been compared to that of hydroxypropyl-beta-cyclodextrin and sulfobutylether-beta-cyclodextrin. Solubility enhancements as high as 4000-fold are observed in 20% (w/v) nicotinamide solution.
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