Beneficial Effects of (Fisch.) Bunge Extract in Controlling Inflammatory Response and Preventing Asthma Features.

(Fisch.) Bunge root is used as herbal medicine for its immunomodulating activities in Chinese medicine. Recently, beneficial properties of on allergic diseases have been proposed.

Bioaccessibility and Anti-Inflammatory Activity of a Chemically Characterized L. Extract Rich in Quercetin Derivatives Optimized by the Design of Experiments.

L. is a highly consumed garden crop rich in biologically active phenolic and organosulfur compounds. This study aimed to assess the bioaccessibility and anti-inflammatory effect of a chemically characterized extract rich in quercetin and its derivatives.

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: and Anti-Inflammatory Characterization.

The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we describe the identification of an indoline-based compound inhibiting both 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase (sEH). analysis of an in-house library identified nine compounds as potential 5-LOX inhibitors.