Reference ranges of HOMA-IR in normal-weight and obese young Caucasians.

Aims: Insulin resistance (IR) may develop very early in life being associated with occurrence of cardiometabolic risk factors (CMRFs). Aim of the present study was to identify in young Caucasians normative values of IR as estimated by the homeostasis model assessment (HOMA-IR) and cutoffs diagnostic of CMRFs.

Methods: Anthropometrics and biochemical parameters were assessed in 2753 Caucasians (age 2-17.

Insulin sensitivity from preschool to school age in patients with severe obesity.

Background: Insulin sensitivity decreases at puberty transition, but little information has been provided on its earlier time-course. Aim of the present study was to describe the time-course of insulin sensitivity in severely obese children at the transition from preschool to school age.

Research Design And Methods: Retrospective study of a cohort of 47 severely obese [Body Mass Index (BMI) ≥99° percentile] preschoolers evaluated twice, once between 2 and 6 years of age, and once before age 8.

Beyond the morphology of the glucose curve following an oral glucose tolerance test in obese youth.

Background: To describe the morphology of glucose curve during the oral glucose tolerance test (OGTT) and any association with glucose tolerance, insulin action and secretion in obese youth.

Study Design: Cross-sectional.

Methods: OGTT data of 553 patients were analysed.