Publications by authors named "Rita Prota"
Microbiota plays a crucial role in intestinal maturation in preterm newborns. The clinical manifestation of the immaturity of the gastro-intestinal tract is called feeding intolerance (FI). This condition may resolve spontaneously or dramatically evolve into necrotizing enterocolitis.
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- * The study found that the transferrin receptor CD71 is increased in Tregs in liver cancer, and its deficiency caused severe health issues in mice due to impaired Treg expansion during early life.
- * CD71 deficiency led to iron overload in the liver, changes in gut microbiota, and suggests that Tregs may contribute to nutritional balance by competing for iron during early bacterial colonization.
Article Synopsis
- Dysregulation of the immune response, particularly through regulatory T cells (Tregs), may be key in the development of necrotizing enterocolitis (NEC) in high-risk neonates.
- A study compared the Treg frequencies in six NEC cases to 52 controls, finding significantly lower Treg levels in NEC cases at birth, which correlated with an increased risk of developing the condition.
- The findings suggest that monitoring Treg frequencies in preterm neonates could serve as an early risk indicator for NEC, helping healthcare providers better manage care for those at risk.
Hyperglycemia (HG) is an independent risk factor of mortality and morbidity in very low birth weight newborns (VLBW). Achievement of high nutritional intakes in the first days of life (DoL) by parenteral nutrition (PN) increases the risk of HG. We aim to assess if a delayed achievement of the PN macronutrient target dose could reduce the occurrence of HG in VLBW.
View Article and Find Full Text PDFEvidences demonstrated that timing of weaning influences long-term growth in full term infants. However, studies on preterm infants are still lacking, and the international guidelines are focused only on healthy full-term newborn, without consensus for preterms. We aimed at evaluating, in a cohort study, the consequences of different timing of weaning on auxological outcomes up to 12 months of corrected age in a population of neonates born with gestational age < 32 weeks or birth weight < 1500 g.
View Article and Find Full Text PDF(1) Background: Preterm birth exposes the infant to the known risk factors for atopic diseases. We aimed to study the neonatal risk factors and to describe the clinical manifestations of atopy, including the march of symptoms, in a cohort of preschool children born preterm. (2) Methods: We enrolled neonates with gestational age < 32 weeks or birth weight < 1500 g.
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