Publications by authors named "Rita Pei-Yeh Chen"
Article Synopsis
- The tau protein is crucial for microtubule stability, and mutations in the tau gene are linked to certain forms of frontotemporal dementia and Alzheimer's disease, where tau and beta-amyloid plaques are present in the brain.
- In this study, transgenic zebrafish models were created to observe the effects of tau-GFP proteins on neuronal cell death, revealing that expressing tau-GFP led to significant neurotoxicity.
- Protective factors like Bcl2-L1 and Nrf2, along with specific chemical treatments, were effective in reducing neuronal death and maintaining tau-GFP in a phosphorylated state, pointing towards the potential of this model for drug discovery in tau-related diseases.*
Layer-by-layer deposition of polyelectrolyte multilayer (PEM) membranes has recently been applied successfully to a number of biomedical applications. This simple and versatile technique provides a broad surface modification platform, for example, for the display of biomolecules such as cell-adhesion peptides. In this work, we investigated the effects of PEM coatings on RGD-immobilization and osteoblast cell culture.
View Article and Find Full Text PDFLayer-by-layer deposition of polyelectrolyte multilayer (PEM) thin films has recently been applied to biomaterial applications. This simple and versatile technique provides a wide variety of potential utilization by insertion of biomolecules such as cell adhesion peptides. In this work dual peptides containing RGD (a cell-binding domain) and LHRRVKI (a heparin-binding domain) were immobilized onto polystyrene by the PEM technique and the effects on osteoblast cell culture were investigated.
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