Publications by authors named "Rita Passantino"
Acute crescentic transformation is a rare but well described event in patients with membranous glomerulonephritis. We report our experience with a 66-year-old Caucasian man presented for rapid decline in renal function. For nearly 10 years, he was suffering from hypertension and mixed sensori-motor polyneuropathy.
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- The metabolic syndrome (MS) is a group of problems that can cause issues with insulin, which is important for managing blood sugar.
- Chronic kidney disease (CKD) is becoming a bigger health issue, but not many people develop severe kidney problems from it.
- There is a link between MS and CKD, but scientists still need to learn more about how they are connected and how they affect the kidneys.
Wegener Granulomatosis is a systemic Anti-Neutrophil Cytoplasmic Autoantibody-associated Vasculitis, affecting small-to-medium vessels. Clinical presentation with simultaneous involvement of kidney and upper and lower respiratory tract is unusual. We report an instructive case of WG, analyzing clinical course, laboratory, and radiological features, kidney, lung, and larynx histological pictures.
View Article and Find Full Text PDFThe putative role of TP53 and p16(INK4A) tumor suppressor genes and Ras oncogenes in the development and progression of salivary gland neoplasias was studied in 28 cases of pleomorphic adenomas (PA), 4 cases of cystic adenocarcinomas, and 1 case of carcinoma ex-PA. Genetic and epigenetic alterations in the above genes were analyzed by Polymerase Chain Reaction/Single Strand Conformational Polymorphism (PCR/SSCP) and sequencing and by Methylation Specific-PCR (MS-PCR). Mutations in TP53 were found in 14% (4/28) of PAs and in 60% (3/5) of carcinomas.
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- Genotype analysis is increasingly important in clinical settings for understanding tumor behavior and treatment responses, but existing methods are often too slow and expensive for routine use.
- Laser pressure catapulting (LPC) microdissection offers a faster, more accurate way to isolate mutated alleles from heterogeneous tumor samples, making it a viable option for clinical practice.
- In a study of 67 colorectal carcinoma cases, LPC demonstrated superior mutation detection capabilities compared to traditional hand-dissection methods, suggesting it should be integrated into standard clinical workflows.