Publications by authors named "Rita Makhlouf"
Article Synopsis
- Antimicrobial resistance, particularly among Gram-negative bacteria, continues to rise, making colistin an essential last-resort antibiotic despite unknown mechanisms of its resistance.
- A study analyzing 32 carbapenem-resistant Klebsiella pneumoniae isolates found varying levels of resistance to colistin, with distinct genetic mutations and lipid A alterations contributing to this resistance.
- The research highlights the need for alternative treatment strategies, such as combination therapies, to effectively manage colistin heteroresistance and improve treatment outcomes.
Temperate phages can shape bacterial community dynamics and evolution through lytic and lysogenic life cycles. In response, bacteria that resist phage infection can emerge. This study explores phage-based factors that influence bacterial resistance using a model system of temperate P22 phage and both inside and outside the mammalian host.
View Article and Find Full Text PDFNeuroblast migration along cellular substrates in the developing porcine brain.
Stem Cell Reports
September 2022
In the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate long distances through complex cellular landscapes to reach their final locations. This process is poorly understood, largely because of technical difficulties in acquiring and studying neurotypical postmortem human samples along with diverging developmental features of well-studied mouse models.
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