Publications by authors named "Rita Komlodi"
Imiquimod (IMQ)-induced skin inflammation is currently the most widely accepted psoriasis animal model, however, it features several limitations. We have modified the IMQ-model to minimize its systemic effects towards effectively maintaining the characteristic skin reactions. The original protocol (OP) uses 62.
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- This study investigated the roles of TRPA1 and TRPV1 channels in a mouse model of psoriasis induced by imiquimod, using selective antagonists and genetically modified mice.
- Findings showed that TRPA1 knockout mice displayed worsened psoriasis symptoms, while inhibiting TRPV1 led to symptom reduction, highlighting TRPV1's primary role in the process.
- The research indicated that activation of TRPA1 could potentially have protective effects in psoriasiform dermatitis, suggesting its significance alongside TRPV1 in mediating skin responses.