Intranasal Scopolamine for Motion Sickness.

Rapid onset, noninjection methods are required to provide "as needed" therapy for motion sickness. Intranasal scopolamine (IN SCOP) is attractive because it can be fast acting and work when gastric motility is slowed. Intranasal administration can provide a time to maximal concentration (T) of drugs (e.

Forehead-mounted reflectance oximetry for in-cockpit hypoxia early detection and warning.

Introduction: Effective hypoxia-related mishap prevention relies upon aircrew rapid recognition of hypoxia symptoms. The objectives of this experiment were twofold: to compare the effectiveness of a forehead-mounted reflectance oximeter and finger-mounted pulse oximeter for application in a hypoxia early warning detection system, and to determine whether the forehead-mounted sensor could be placed within an aviation helmet.

Methods: Subjects donned an aviation flight mask and were instrumented with a forehead reflectance oximeter, a finger pulse oximeter, a blood pressure cuff, and a skin temperature sensor.

A single dose of armodafinil significantly promotes vigilance 11 hours post-dose.

Objective: This study was conducted to test the ability of armodafinil to promote vigilance among air traffic control operators 8 to 11 hours post-dose.

Methods: Forty-eight U.S.

The efficacy of low-dose intranasal scopolamine for motion sickness.

Introduction: Scopolamine is an effective motion sickness prophylactic, but oral and transdermal formulations are slowly absorbed. To enhance absorption and potentially efficacy, an intranasal formulation of scopolamine (INSCOP) was tested.

Method: There were 16 motion sickness susceptible subjects with an average age of 23.