Translokin (Cep57) interacts with cyclin D1 and prevents its nuclear accumulation in quiescent fibroblasts.

Nuclear accumulation of cyclin D1 because of altered trafficking or degradation is thought to contribute directly to neoplastic transformation and growth. Mechanisms of cyclin D1 localization in S phase have been studied in detail, but its control during exit from the cell cycle and quiescence is poorly understood. Here we report that translokin (Tlk), a microtubule-associated protein also termed Cep57, interacts with cyclin D1 and controls its nucleocytoplasmic distribution in quiescent cells.

Is major depression adequately diagnosed and treated by general practitioners? Results from an epidemiological study.

Objectives: The aim of this study was to (1) to explore the validity of the depression diagnosis made by the general practitioner (GP) and factors associated with it, (2) to estimate rates of treatment adequacy for depression and factors associated with it and (3) to study how rates of treatment adequacy vary when using different assessment methods and criteria.

Methods: Epidemiological survey carried out in 77 primary care centres representative of Catalonia. A total of 3815 patients were assessed.

Frequent attendance in primary care: comparison and implications of different definitions.

Background: The diversity of definitions of frequent attendance in the literature hampers comparison of their precision, validity, and associated factors.

Aim: To examine different definitions of frequent attendance in order to identify the sociodemographic and clinical factors associated with frequent attendance in primary care, according to each definition.

Design Of Study: One-phase cross-sectional study.