Perinatal outcomes in women with cystic fibrosis: Data from the Italian Cystic Fibrosis Registry.

Introduction: Data from the Italian Cystic Fibrosis Registry concerning pregnancies in the period 2010-2015 were used to investigate the association between the preconception clinical status and perinatal outcomes of women with cystic fibrosis (CF).

Material And Methods: The assessed clinical variables were genotype, age at the time of conception, body mass index (BMI) and the percentage of predicted forced expiratory volume in the first second (ppFEV ). The analyzed outcomes were gestational age, birthweight and the frequency of cesarean deliveries.

Whole blood fatty acid analysis with micromethod in cystic fibrosis and pulmonary disease.

Objectives: To assess fatty acid (FA) profiles in whole blood of 90 cystic fibrosis patients (CF) and 30 control subjects (C) and to correlate FA changes to the severity of respiratory disease.

Methods: Whole blood FA were assessed by GC with a micromethod-based analysis.

Results: Saturated and monounsaturated FA are higher, whereas polyunsaturated FA are lower in CF versus C with reduction of total n-6 FA, 22:5n-3 and 22:6n-3 (DHA).