Hypertension plus diabetes mimics the cardiomyopathy induced by nitric oxide inhibition in rats.

Study Objectives: We compared the myocardial lesions caused by the long-term inhibition of nitric oxide (NO) biosynthesis with those associated with renovascular hypertension (two-kidney, one-clip model [2K-1C]) and superimposed streptozotocin-induced diabetes mellitus (DM).

Design: Prospective trial.

Setting: University laboratory.