A Cross-Sectional Evaluation of the Virtual Outpatient Management of People With Mpox.

Background: To report on the implementation and outcomes of a virtual ward established for the management of mpox during the 2022 outbreak, we conducted a 2-center, observational, cross-sectional study over a 3-month period.

Methods: All patients aged ≥17 years with laboratory polymerase chain reaction-confirmed monkeypox virus managed between 14 May and 15 August 2022, at the Hospital for Tropical Diseases at University College London Hospitals National Health Service (NHS) Foundation Trust and sexual health services at Central North and West London NHS Foundation Trust, were included. Main outcomes included the proportion of patients managed exclusively on the virtual ward, proportion of patients requiring inpatient admission, proportion of patients with human immunodeficiency virus, and duration of lesion reepithelialization.

Characteristics of HIV post-exposure prophylaxis recipients at six English sexual health clinics during COVID-19.

Objectives: Disruption to sexual health services during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; coronavirus disease 2019 [COVID-19]) pandemic may have adversely affected the provision of HIV post-exposure prophylaxis (PEP), possibly leading to increased HIV transmission. Globally, services have reported a reduction in the number of PEP prescriptions dispensed during lockdowns, although it is unclear why. Our primary objective was to describe the temporal change in weekly HIV PEP dispensed at six English sexual health clinics in 2020.

Improving the antenatal and post-partum management of women presenting to Sexual Health Services with positive syphilis serology through audit.

The incidence of congenital syphilis remains low in the UK, but the morbidity and mortality to babies born to women who are untreated for the condition make testing for the disease antenatally one of the most cost-effective screening programmes. Women attending North Middlesex Hospital, UK with a positive syphilis test at their antenatal booking visit are referred to St Ann's Sexual Health Clinic, London, for management and contact tracing. We were concerned that our initial audit revealed that a large proportion of women referred to our service never attended and recorded partner notification was poor.

Atypical presentations of genital herpes simplex virus in HIV-1 and HIV-2 effectively treated by imiquimod.

Atypical presentations of genital herpes simplex virus have been described in HIV. We report two cases with hypertrophic presentations which were effectively treated with imiquimod, one of which is the first reported case occurring in a patient with HIV-2.

What is your patient taking? Dietary supplements in an HIV-positive patient.

We report on an HIV-positive individual who developed a biochemical hepatitis likely to be due to excessive intake of dietary supplements, highlighting the need for clinicians to be vigilant over their use.

Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin.

Objective: To evaluate treatment outcome of acute hepatitis C virus (HCV) in HIV-positive individuals.

Design: Open-label, prospective study conducted in London, January 1997-December 2003.

Methods: Patients in whom acute HCV infection had been diagnosed had sequential HCV RNA levels measured at 0, 4, 12, 24, 32, and 48 weeks.

Retrospective review of the correlation of symptoms, signs and microscopy with the diagnosis of Chlamydia trachomatis in men.

We have investigated the correlation of symptoms, signs and microscopy on the detection of Chlamydia trachomatis infection in men attending our clinic. One hundred and eleven men diagnosed with chlamydia over an 11-month period in our clinic were reviewed. Of these, 70 (63%) were symptomatic and 41 (37%) were asymptomatic.

Effect of treatment for sexually transmitted disease on HIV transmission.

The rapid increase in the worldwide prevalence of HIV infection and sexually transmitted diseases (STDs) has prompted research into the effect of STDs on HIV transmission as well as that of STD treatment interventions on HIV incidence. There is conclusive evidence that STDs act as co-factors for HIV transmission but STD treatment intervention studies have demonstrated contradictory results. Current evidence on the effect of STDs on HIV transmission and community-based randomised controlled trials of STD interventions in Uganda and Tanzania is discussed.

Newly diagnosed HIV infection in an octogenarian: the elderly are not 'immune'.

Case Report: an 83-year-old heterosexual man with malaise tested positive for HIV infection antibodies and has responded well to triple antiretroviral therapy.

Discussion: HIV should not be discounted on the basis of age when an elderly patient presents for the investigation of illness.