Publications by authors named "Risto K Huupponen"
Article Synopsis
- Leptin is a hormone produced by fat cells that reflects body fat levels, and while rare genetic mutations cause leptin deficiency leading to obesity, common genetic variants affecting leptin have not been found.
- A genome-wide association study with over 52,000 participants identified five genetic loci linked to circulating leptin levels, with most associations remaining even after adjusting for body mass index (BMI).
- The study highlights the role of adipogenin in the SLC32A1 locus as a key factor in leptin regulation, offering new insights into how leptin affects body weight and metabolism.
Background: Although register-based studies on statin adherence are increasing, for administrative data, little is known about the explanatory power of the predictors that explain adherence.
Objective: The aim was to explore the ability of variables in administrative data to predict statin adherence in an unselected, universally insured population and, especially, to explore dispensation delay (time elapsed between prescription and dispensation) and out-of-pocket costs as explanatory factors.
Methods: Statin initiators who were aged 45 to 75 years in 2000-2004 (n = 247, 051) were identified in the Finnish Prescription Register.
Aims: Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.
Methods And Results: We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study.
Relationship between leptin and C-reactive protein in young Finnish adults.
J Clin Endocrinol Metab
December 2007
Context: Leptin and C-reactive protein (CRP) concentrations are increased in inflammation, and both have been linked to increased risk for cardiovascular diseases.
Objective: The objective of the study was to explore in a population-based sample whether the relation between leptin and CRP is independent of obesity level and whether genetic causes of CRP elevation contribute to leptin levels.
Design: This was a population-based study including 1862 young adults (971 women; 891 men) aged 24-39 yr.