Publications by authors named "Rishna Shrestha"
Article Synopsis
- Mitochondrial iron import is crucial for creating iron-sulfur clusters and synthesizing heme, with two main iron importers identified in mammals: Mfrn1 and Mfrn2.
- Mice lacking Mfrn2 have reduced male fertility due to lower sperm counts and motility, while a specific loss of Mfrn1 in liver cells decreases mitochondrial iron and affects energy production proteins.
- Both Mfrn1 and Mfrn2 are essential for maintaining mitochondrial iron levels and support cell proliferation, indicating their key role in iron transport during active cellular growth.
Article Synopsis
- Erythropoietin (EPO) signaling is crucial for the final stages of red blood cell development, but how it affects iron metabolism remains unclear.
- Research identified a protein called FAM210B that plays a key role in processes like hemoglobin formation and cell division during this maturation stage.
- FAM210B is not directly an iron transporter but helps in iron import to mitochondria, which is necessary for producing heme and iron-sulfur clusters essential for red blood cell function.
Chediak-Higashi syndrome is an autosomal recessive disorder that affects vesicle morphology. The Chs1/Lyst protein is a member of the BEige And CHediak family of proteins. The absence of Chs1/Lyst gives rise to enlarged lysosomes.
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