Publications by authors named "Rishika Chugh"
Article Synopsis
- The study examines pregnancy outcomes in women with inflammatory bowel disease (IBD) and explores the safety of newer biologic treatments (ustekinumab and vedolizumab) compared to other medications and no exposure.
- Researchers collected data from 1,669 pregnancies, finding no significant risks of complications like miscarriage or low birth weight linked to these biologics and noted that preterm birth rates were lower in the ustekinumab group.
- The study concludes that exposure to ustekinumab and vedolizumab during pregnancy does not increase risks for maternal or fetal health compared to other treatments.
Article Synopsis
- Inflammatory bowel disease (IBD) is a long-term health issue that needs careful checking, and digital tools can help patients track their condition from home.
- The IBD Virtual Care Chat was created to allow patients to share their health data and get support from doctors online.
- Out of nearly 3,000 patients, many used the chat tool, and those with certain symptoms liked it more, showing that digital health can work well for IBD care.
Background: Upadacitinib is a selective Janus kinase inhibitor approved for the management of ulcerative colitis and is under evaluation for the management of Crohn's disease [CD] in Phase 3 clinical trials.
Aims: Our goal was to describe our real-world experience with upadacitinib in CD.
Methods: This is a two-centre retrospective cohort study of adult patients with moderate to severe CD on upadacitinib.
The prevalence of inflammatory bowel disease is continuing to increase worldwide and is more commonly diagnosed in women of reproductive age. Individuals with Crohn's disease may have inaccurate perceptions regarding the rate of infertility, heritability, and the safety of taking therapies for Crohn's disease during pregnancy, all of which greatly affect their decisions surrounding family planning. Given this area of need for both patients and providers, in this article, we have included the latest evidence on the impact of Crohn's disease on fertility, heritability, pregnancy outcomes, and the safety of medications for Crohn's disease during pregnancy and lactation.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) have transformed the management of advanced malignancies but are associated with diarrhea and colitis. The objective of our systematic review and meta-analysis was to determine the incidence and outcomes of ICI-associated diarrhea and colitis. Bibliographic databases were searched through August 13, 2019, for observational studies of ICI therapy reporting the incidence and/or treatment of diarrhea or colitis.
View Article and Find Full Text PDFCPI-17 (C-kinase-activated protein phosphatase-1 (PP1) inhibitor, 17kDa) is a cytoplasmic protein predominantly expressed in mature smooth muscle (SM) that regulates the myosin-associated PP1 holoenzyme (MLCP). Here, we show CPI-17 expression in proliferating cells, such as pancreatic cancer and hyperplastic SM cells. Immunofluorescence showed that CPI-17 was concentrated in nuclei of human pancreatic cancer (Panc1) cells.
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