Perceptions of Indian neurosurgeons about medicolegal issues and malpractice suits.

Objective: Despite the rising trend of medicolegal challenges in India, there is an absolute dearth of literature from India on this issue. The authors conducted a survey, to their knowledge a first of its kind, to assess the perceptions of Indian neurosurgeons about the medicolegal challenges faced in everyday practice.

Methods: An anonymous online survey performed using Google Forms was widely circulated among neurosurgeons practicing in India via email and social media platforms.

Synthesis, analytical analysis, and medicinal aspect of novel benzimidazoles and their metal complexes.

Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy. The ligands showed binding to most of the organs, known to express CCK receptors in biodistribution studies. Cholecystokinin (CCK1 and CCK2) receptor binding affinities of these analogs (IC50) are 0.

The anatomic suitability of the C2 vertebra for intralaminar and pedicular fixation: a computed tomography study.

Background Context: Several methods have been used to stabilize the atlantoaxial joint, including the use of C2 pedicle and laminar screws. No report has used computed tomography (CT) angiograms to compare the risk to the vertebral artery or assess the suitability for each fixation technique.

Purpose: To compare the suitability of C2 pedicle versus laminar screws using CT angiograms.

Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury.

Background And Purpose: Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue and replace the ischemic tissue caused by HI and to restore function. However, the mechanisms by which stem cell transplants induce functional recovery are yet to be elucidated.

Functional engraftment of the medial ganglionic eminence cells in experimental stroke model.

Currently there are no effective treatments targeting residual anatomical and behavioral deficits resulting from stroke. Evidence suggests that cell transplantation therapy may enhance functional recovery after stroke through multiple mechanisms. We used a syngeneic model of neural transplantation to explore graft-host communications that enhance cellular engraftment.

An anatomic study of the S2 iliac technique for lumbopelvic screw placement.

Study Design: An anatomic study conducted on cadaveric specimens.

Objectives: The objectives of the study were (1) to determine course of S2 lumbopelvic screws with reference to the articular cartilage of the sacroiliac joint, (2) to determine the length and trajectory of screws placed using anatomic placement techniques, and (3) to determine vital structures at risk using this technique.

Summary Of Background Data: Multiple techniques exist for fixation distal to S1 including alar screws, iliac post bolts, and transiliac rods.

Staged pelvic closure of extreme pubic diastasis in the exstrophy-epispadias complex.

Purpose: Staged pelvic closure has been shown to be beneficial in achieving pubic approximation in children with the exstrophy-epispadias complex. We have continued to use this procedure in children with extreme pelvic diastasis and have updated our experience.

Materials And Methods: We performed closure of the pelvis in 15 patients 12 months to 14 years old presenting with a pubic diastasis of at least 8 cm (range 8 to 16).

Temporary internal distraction as an aid to correction of severe scoliosis.

Background: Halo traction is a well-recognized adjunct for correcting severe complex rigid scoliotic curves, but it is associated with complications and is contraindicated in the presence of fixed cervical instability, kyphosis, or stenosis. In addition, halo traction often requires prolonged hospital stays and is not welcomed by all families. These limitations led to consideration of temporary internal distraction as an alternative.

Adolescent idiopathic scoliosis: modern management guidelines.

Adolescent idiopathic scoliosis (AIS), a structural lateral curvature of the spine of uncertain etiology, is the most common cause of spinal deformity in adolescents. In its most severe form, AIS is characterized by progressive spinal curvature that may lead to a permanent deformity. Thus, the goal of treatment is early detection and prevention of progression.

Diagnosis and treatment of common fractures in children: femoral shaft fractures and supracondylar humeral fractures.

Femoral shaft fractures and supracondylar elbow fractures are two of the most common major pediatric injuries managed by the general orthopedic surgeon. Therapeutic choices frequently are influenced by many factors, including associated injuries, fracture type, and the child's age, social situation, and economic issues. Nonsurgical management of femoral shaft fractures has been a preferred and cost-effective treatment for most age groups, but recently the use of surgical techniques has gained popularity with the overall goal of rapid mobilization of the child.

Comparative case study of two biomedical research collaboratories.

Background: Working together efficiently and effectively presents a significant challenge in large-scale, complex, interdisciplinary research projects. Collaboratories are a nascent method to help meet this challenge. However, formal collaboratories in biomedical research centers are the exception rather than the rule.