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Publications by authors named "Rishav Nag"

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Elucidating the pathobiology of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) with its expanded RNA structure formation and proteinopathy.
Krishna Singh Sakshi Shukla Uma Shankar Neha Jain Rishav Nag

Sci Rep

November 2024

Article Synopsis
  • * CANVAS, a neurodegenerative disorder, is specifically associated with the expansion of the (AAGGG) repeat in the RFC1 gene, but its exact pathological mechanisms are not fully understood.
  • * Recent findings suggest that GQ structures formed by these repeats may contribute to toxic protein-related mechanisms in CANVAS, as they affect RNA processing and interact with key RNA-binding proteins, ultimately guiding future therapeutic strategies.
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