Synthesis, Characterization, and Cytotoxicity of Morpholine-Containing Ruthenium(II) -Cymene Complexes.

Morpholine motif is an important pharmacophore and, depending on the molecular design, may localize in cellular acidic vesicles. To understand the importance of the presence of pendant morpholine in a metal complex, six bidentate N,O-donor ligands with or without a pendant morpholine unit and their corresponding ruthenium(II) -cymene complexes (-) are synthesized, purified, and structurally characterized by various analytical methods including X-ray diffraction. Complexes - crystallized in the 2/ space group, whereas and crystallized in the 1̅ space group.