Publications by authors named "Risha Chakraborty"
Article Synopsis
- Mutations in the Gba gene and SNCA gene contribute significantly to cognitive decline in models of Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB), affecting how these diseases manifest in motor and cognitive functions.
- Gba L444P mutant mice showed early cognitive impairments without motor deficits, while SNCA transgenic mice exhibited motor issues without cognitive changes, and the double mutant mice had both cognitive and motor decline.
- The research found that Gba mutations lead to synaptic vesicle cycle defects in neurons independently of α-synuclein pathology, suggesting that these mutations highlight important mechanisms in cognitive decline beyond traditional α-synuclein aggregation.
