New Formulations of Isotretinoin for Acne Treatment: Expanded Options and Clinical Implications.

Background: Isotretinoin is a widely used and effective drug in the treatment of severe, recalcitrant, nodular acne. However, its poor aqueous solubility limits oral bioavailability and requires administration with a high-fat, high-calorie meal (HF/HC) for optimal absorption; poor patient adherence may decrease effective dosing and treatment efficacy.

Objective: This review covers the properties of the lidose isotretinoin and micronized isotretinoin formulations and their use in acne therapy.