Nox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cells.

Unlabelled: Transforming growth factor (TGF)-β induces epithelial-mesenchymal transition (EMT) in pancreatic adenocarcinoma. In this study, we investigated how NADPH oxidase (Nox) 4-generated reactive oxygen species (ROS) regulate TGF-β-induced EMT in pancreatic cancer cells.

Materials And Methods: Pancreatic cancer cells were transfected with Nox4 siRNAs or PTP1B mutants and subjected to TGF-β-induced EMT assay.

Esophageal cancer associated with other primary cancers--historical comparison of clinicopathologic features in 359 esophageal cancer patients.

Background/aims: We historically investigated the clinicopathologic features of esophageal cancer associated with other primary cancers (OPC), and discussed differences between the last decade and the previous period.

Methodology: A total of 359 patients with esophageal cancer treated between 1981 and 2006 were enrolled. They were divided into 2 groups; 213 patients between 1981 and 1996 (Group-A), and 146 patients between 1997 and 2006 (Group-B).

Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake.

This is the first case of gastric schwannoma that exhibited increased accumulation of [(18)F] fluorodeoxyglucose (FDG) on positron emission tomography (PET) imaging. The patient was a 60-year-old woman in whom esophagogastroduodenoscopy showed a submucosal tumor, about 25 mm in size, in the upper body of the stomach, with ulceration at the top of the tumor. Endoscopic ultrasonography revealed a well-defined hypoechoic mass located in the proper muscle layer of the stomach.

Aggressive angiomyxoma mimicking inguinal hernia in a man.

We report the case of a 37-year-old Japanese man who presented with a left lower abdominal mass that was initially interpreted clinically as an inguinal hernia. The patient reported a swelling in his left lower abdomen over the past 6 months. Magnetic resonance imaging revealed a left inguinal mass extending from the left spermatic cord to the left inguinal subcutaneous layer.